Genetics in Primary Care Institute (AAP)
The goal of this site is to increase collaboration in the care of children with known or suspected genetic disorders. It includes health supervision guidelines and other useful resources; represents a collaboration among the Health Resources & Services Administration, the Maternal and Child Health Bureau, and the American Academy of Pediatrics.
Akins RS, Angkustsiri K, Hansen RL.
Complementary and alternative medicine in autism: an evidence-based approach to negotiating safe and efficacious interventions with families.
Neurotherapeutics. 2010;7(3):307-19. PubMed abstract / Full Text
This review focuses on helping clinicians identify resources and develop strategies they may use to effectively negotiate safe and effective use of complementary and alternative medicine (CAM) treatments with families of children with autism spectrum disorders (ASD), as well as other neurodevelopmental disorders.
Anagnostou E, Hansen R.
Medical treatment overview: traditional and novel psycho-pharmacological and complementary and alternative medications.
Curr Opin Pediatr. . 2011;23(6):621-7. PubMed abstract
Accumulating data suggest a series of existing medications may be useful in ASD and large randomized clinical trials are necessary to evaluate safety and efficacy of both pharmaceuticals and alternative treatments.
Andersen IM, Kaczmarska J, McGrew SG, Malow BA.
Melatonin for insomnia in children with autism spectrum disorders.
J Child Neurol. 2008;23(5):482-5. PubMed abstract
Cheuk DK, Wong V, Chen WX.
Acupuncture for autism spectrum disorders (ASD).
Cochrane Database Syst Rev. 2011(9):CD007849. PubMed abstract / Full Text
To determine the effectiveness of acupuncture for people with ASD in improving core autistic features, as well as communication, cognition, overall functioning and quality of life, and to establish if it has any adverse effects.
Chez MG, Buchanan CP, Aimonovitch MC, Becker M, Schaefer K, Black C, Komen J.
Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders.
J Child Neurol. 2002;17(11):833-7. PubMed abstract / Full Text
L-Carnosine, a dipeptide, can enhance frontal lobe function or be neuroprotective. It can also correlate with gamma-aminobutyric acid (GABA)-homocarnosine interaction, with possible anticonvulsive effects. Although the mechanism of action of L-carnosine is not well understood, it may enhance neurologic function, perhaps in the enterorhinal or temporal cortex.
Gold C, Wigram T, Elefant C.
Music therapy for autistic spectrum disorder.
Cochrane Database Syst Rev. 2006(2):CD004381. PubMed abstract / Full Text
Music therapy uses music and its elements to enable communication and expression, thus attempting to address some of the core problems of people with ASD. The findings indicate that music therapy may help children with autistic spectrum disorder to improve their communicative skills. More research is needed to examine whether the effects of music therapy are enduring.
Hediger ML, England LJ, Molloy CA, Yu KF, Manning-Courtney P, Mills JL.
Reduced bone cortical thickness in boys with autism or autism spectrum disorder.
J Autism Dev Disord. 2008;38(5):848-56. PubMed abstract
James S, Montgomery P, Williams K.
Omega-3 fatty acids supplementation for autism spectrum disorders (ASD).
Cochrane Database Syst Rev. 2011(11):CD007992. PubMed abstract / Full Text
Reviewed the efficacy of omega-3 fatty acids for improving core features of ASD and associated symptoms. To date there is no high quality evidence that omega-3 fatty acids supplementation is effective for improving core and associated symptoms of ASD.
Krishnaswami S, McPheeters ML, Veenstra-Vanderweele J.
A systematic review of secretin for children with autism spectrum disorders.
Pediatrics. 2011;127(5):e1322-5. PubMed abstract / Full Text
Secretin has been studied extensively in multiple randomized controlled trials, and there is clear evidence that it lacks benefit. The studies of secretin included in this review uniformly point to a lack of significant impact of secretin in the treatment of ASD symptoms.
Nye C, Brice A.
Combined vitamin B6-magnesium treatment in autism spectrum disorder.
Cochrane Database Syst Rev. 2005(4):CD003497. PubMed abstract
Due to the small number of studies, the methodological quality of studies, and small sample sizes, no recommendation can be advanced regarding the use of B6-Mg as a treatment for autism.
Rossignol DA, Frye RE.
Melatonin in autism spectrum disorders: a systematic review and meta-analysis.
Dev Med Child Neurol. 2011;53(9):783-92. PubMed abstract / Full Text
Melatonin administration in ASD is associated with improved sleep parameters, better daytime behavior, and minimal side effects.
Williams K, Wray JA, Wheeler DM.
Intravenous secretin for autism spectrum disorders (ASD).
Cochrane Database Syst Rev. 2012;4:CD003495. PubMed abstract / Full Text
Over 900 children were recruited for the secretin trials. Meta-analysis of data was not possible but there is now consistency of findings, with RCTs of the efficacy of secretin in autism not showing improvements for core features of ASD.